January-March 2018

Incidence and outcome of retinopathy of prematurity in neonates and correlation with risk factors

Nirali F Sanghvi1*, Vaishali R Chanpura2

13rd year Resident Doctor, 2Assistant Professor, Department of Paediatrics, Medical College and SSG Hospital, Vadodara


BACKGROUND: To study the incidence and risk factors predisposing to retinopathy of prematurity (ROP) in at-risk newborns at SNCU of a tertiary care hospital in Vadodara METHODS: Preterm infants with birth weight < 1500gm and gestation <=34 weeks were screened for ROP at 4 weeks after birth or 31-33 weeks post conceptional age, whichever was later. Infants with birth weight 1500 to 2000 gm and gestation >34 weeks were screened only if they had additional risk factors. Those found to have high risk ROP were treated. RESULTS: The incidence of ROP in 113 infants who were screened was 30.9%. No ROP was found in infants weighing >2000gm or with a gestational age more than 37weeks. Risk factors predisposing to ROP (P<0.05) were oxygen therapy, apnoea, ventilation, sepsis, anaemia, blood product transfusion, ventilation, shock requiring vasopressors and multiple gestation. Out of the 37 infants who developed ROP, 17 (48.5%) needed invasive management. CONCLUSION: Approximately half of the infants with ROP needed invasive management the outcome of which was good. Risk factors predisposing to ROP were Gestational Age and Birth weight alone and alongwith the various risk factors like oxygen therapy, apnoea, mechanical ventilation, sepsis, anaemia, blood transfusion, Shock and Multiple Gestation. The occurrence of ROP is trending towards a rise including newborns with higher birth weight and gestational Age in developing countries; hence necessitating the need to revise the guidelines for Screening Newborns for presence of ROP to include babies with higher Birth weight and Gestational Age.

Keywords: ROP, prematurity, gestational age, birth weight, Risk Factors

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