January-March 2018

Significance of Sgot & Sgpt Ratio ( De Ritis Ratio) & Ggt Levels In Patients of Liver Cirrhosis With And Without History of Alcoholism

Anju R1*, Khushal Shah2

1,23rd year resident, Department of Biochemistry, S.S.G Hospital & Baroda medical college, Vadodara, India.



BACKGROUND AND OBJECTIVES: Liver is the 2nd largest internal organ in the human body involved in metabolism, detoxification and purification of blood. Chronic and excessive alcohol ingestion is one of the major causes of liver disease. A biochemical clue is the ratio of SGOT to SGPT (2:1), reflecting the low level of activity of SGPT in people with alcoholic liver disease. Objectives are to find out the levels of SGPT, SGOT and GGT levels in patients of cirrhosis with and without history of alcoholism and to compare these levels and calculate the SGOT to SGPT ratio. METHODS: Crosssectional study conducted in Medical College Vadodara. 60 male patients are included and divided into two groups. Group A – 40 patients who were alcoholics Group B – 40 patients who were nonalcoholics. SGPT, SGOT, GGT, were assayed using modified IFCC method on cobas c-311 Fullyauto Analyzer & SGOT/SGPT ratio was analyzed. Statistical analysis was done using unpaired t test and the significance calculated using Medcalc software. RESULTS: SGPT, SGOT, GGT levels showed very high statistically significant difference between two groups. GGT levels found to be very high in group A compared to group B. SGOT/SGPT (De-ritis ratio) 2.3 in group A and 1.5 in group B and showed very high statistically significant difference. CONCLUSION:  In this study the Deritis ratio is significantly raised in Group A patients with - >2.0 & in Group B >1.0. Serum GGT levels are also raised significantly in patients with alcoholic cirrhosis compared to SGPT and SGOT levels.


Keywords: Alcoholism, De ritis Ratio, Cirrhosis

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