January-March 2018

A Study Showing Association between Hscrp and Fasting Plasma Glucose in Overweight and Obese Patients in a Tertiary Care Centre in Gujarat, India

Hiren Makwana1, Varshit Hathi2*

1,2MD General Medicine Department of General Medicine Pandit Deendayal Upadhyay Medical College, Jamnagar road, Rajkot-360001


BACKGROUND: Obesity is rapidly growing health problem in both developed and developing countries. In adults obesity is associated with hyperinsulinemia, insulin resistance, dyslipidemia, and vascular dysfunction. C-Reactive Protein (CRP), formerly considered solely as a biomarker for inflammation, is now viewed as a prominent partaker in endothelial dysfunction and atherosclerosis AIMS & OBJECTIVES: The present study aims to establish correlation between elevated hscrp levels and elevated fasting plasma glucose levels in overweight and obese patients. MATERIAL & METHODS: The present study was undertaken at a tertiary care centre in Gujarat, India for a period of 2 years. Inclusion criteria includes healthy males and females more than 18 years with body mass index ≥ 25kg/m2 whereas all the comorbidities like diabetes mellitus, hypertension, stroke, coronary artery disease are excluded. RESULTS: There was statistically significant positive correlation between elevated Fasting Blood Sugar(FBS) level and HSCRP level (elevated FBS : normal FBS ratio of HSCRP was 3.26 : 1.85, Z value 3.35, p value <0.0012). CONCLUSION: Thus there is a direct correlation with increased hscrp and fasting plasma glucose which in itself a risk factor for atherosclerotic cardiovascular diseases and metabolic syndrome.

Keywords: HSCRP, Obesity, Body Mass Index (BMI)

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