January-March 2018

A Descriptive Study on Prevalence and Outcome of Human Leptospirosis Case with Various Co-infections at Tertiary Care Hospital, South Gujarat

Ashvin Vasava1, Arvind Kumar Sharma2

1Associate Professor, 2Assistant Professor, Department of Medicine, Government Medical College, Surat


BACKGROUND AND OBJECTIVES: Leptospirosis, an emerging global public health problem, is endemic in South Gujarat regions. The aim of study was to explore the epidemiological and clinical spectrum of leptospirosis and to examine existence of co-infections. METHODS: This was a retrospective, observational and single-centre study. Patients who were admitted with confirmed diagnosis of leptospirosis to our tertiary care centre between January 2012 and December 2014were retrospectively included in this study. RESULTS: A total of 79 patients who were admitted with confirmed diagnosis of leptospirosis to our tertiary care centre are included in this study.Among included patients, rural residents (n=76; 96.2%) and male patients (n=54; 68.4%) were predominant. Majority of the patients belong to age group of 40-59 years (n=41; 51.9%) and 20-39 years (n=30; 38%).All the included patients were admitted during July to October. Chemoprophylaxis (doxycycline 200 mg for 8 weeks) was received by only two (2.5%) patients. A total of 8 patients were co-infected with hepatitis-C virus (n=2), malaria (n=3) and dengue (n=3).Renal failure (serum creatinine >1.4mg/dL) was the commonest complication (n=77; 97.5%) of the disease followed by respiratory failure requiring mechanical ventilation (n=29; 36.7%) and hemorrhagic pneumonia (n=16; 20.3%). CONCLUSION: The findings of the present study raise awareness of the physicians about occurrence of parasitic, viral or bacterial co-infections in leptospirosis patients.

Keywords: leptospirosis; epidemiological study; co-infections; complications; zoonotic disease

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