A Study On Neuromuscular Blocking Effect Of Rocuronium Bromide in Anesthesia In A Tertiary Care Hospital

Hardik Z Patel1, Avruti R Kacha2

1Assistant Professor, Dept. Of Anesthesia, GMERS Medical College Valsad, Gujarat, India. 2Consultant, Dept. Of Anesthesia & critical care , Baby memorial Hospital, Calicut, Kerala India.


BACKGROUND AND OBJECTIVES: Rocuronium bromide is a non-depolarizing muscle relaxant, with a short onset time, an intermediate duration of action and rapid recovery characteristics coupled with cardiovascular stability, with no histamine release or other side effects. The present study was conducted with an objective to study onset of action (time of maximum depression of T1), duration of action, pharmacodynamic effects and recovery profile of rocuronium bromide. METHODS: The present study is cross-sectional study conducted on patients posted for general surgeries and ENT surgeries of intermediate duration. The time to achieve maximum blockade and the clinical duration of action were also noted by twitch stimulation using biometer accelograph. RESULTS: In our study 18% of the patients showed maximum depression of T1 at 60 seconds when laryngoscopy was done and 42% of the patients showed maximum depression of T1 at 80 seconds, the time by which the endotracheal intubation was completed. In 12% of patients it took more than 100 seconds for the maximal depression of T1. The mean +SD for maximum depression of T1 is 78.80+20.76 which indicates the onset time of rocuronium bromide with the dose of 0.6 mg kg-1. CONCLUSION: Rocuronium in the dose of 0.6 mgkg-1 for induction of anaesthesia and 0.15 mg kg-1IV for maintainace of anaesthesia can be used as a part of rapid sequence induction, provided there is no anticipated difficulty in intubation.

Keywords: Neuromuscular blockade, rocuronium, accelerograph

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