January-March 2018

Relationship between Serum Bilirubin levels and Coronary Artery Disease

W. Ajay sam kumar1, K.V.S.S.R. Abhilash2

1Senior resident, Department of General Medicine, Mahatma Gandhi Medical college and research Institute, Pondicherry 607402 2Post Graduate, Department of Cardiology, Care Hospitals, Vishagapatnam- 530002


BACKGROUND AND OBJECTIVES: Bilirubin, the bile pigment was initially considered as a toxic waste but later known to be a physiological antioxidant, with protective effect on prevention of coronary artery disease (CAD) and atherosclerosis. CAD, being a burden in the both developed and developing countries, it is very essential to find the parameters that prevents and provokes the CAD. Thus this study was planned to find the association between serum bilirubin level and coronary artery disease. METHODS: This study was done among the patients attending outpatient department of general medicine in Vinayaka Mission’s Kirupananda variyar Medical College & Hospital, Salem during the period December 2015 to January 2016. 100 cases of coronary artery disease were included and 100 controls were included after matching age and other co-morbid conditions. After taking written informed consent, detailed history, general and systemic examinations were done along with blood investigations. Data were analyzed using SPSS 16. RESULTS: The mean age of patients with CAD and non CAD was found to be 61.87±15.9 and 56.47±11.03 years. Mean serum total bilirubin was reported to be 0.8967±1.7 and 0.4774±.15 among subjects with CAD and non CAD, respectively, which was also found to be statistically significant (0.017< 0.05). CONCLUSION: Serum bilirubin could be used to foresee the risk of CAD in case of high risk population and it can be measured easily in the clinical laboratory and applied in medical practices.

Keywords: Serum Bilirubin, Caronary Artery Disease, CAD

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