April - June 2019

Prevalence of Diabetes in Tuberculosis, Microbiological and Clinicoradiological features of Tuberculosis in Diabetes

Mahsheeba Asbin1, Irfan Kandal2, Asbin Aziz3, Bachhu Singh Varma, Sonia Elizabeth Ninan1, Sharath Chandra KS1

1Post-graduate, Department of Pulmonary Medicine, Yenepoya Medical College
2 Associate Professor, Department of Pulmonary Medicine, Yenepoya Medical College
3Senior resident, Department of General Medicine, Yenepoya Medical College
4HOD ,Department Of Respiratory Medicine, Yenepoya Medical College Hospital, Mangalore.


BACKGROUND AND OBJECTIVES: Tuberculosis is a recognised cause of death especially among population of low socio-economic status and superimposed diabetes even exacerbates the scenario. People affected with both diabetes and tuberculosis have a worse outcome compared to non-diabetic patients. METHODS: A Hospital Based cross sectional study was conducted in tuberculosis patients in Yenepoya medical college hospital over a period of 3 months in 2017 to know the prevalence of diabetes among pulmonary and extra-pulmonary TB patients in Category I, Category II, multi-drug resistant (MDR) and extensive drug resistant (XDR) patients. Clinico-radiological and microbiological characteristics of patients with Pulmonary tuberculosis and Diabetes mellitus were also noted. 150 TB patients were enrolled in our study. RESULTS: The prevalence of diabetes in tuberculosis patients was found to be 24.7%. The majorities of TB patient were previously diagnosed with Diabetes Mellitus (16%) and newly diagnosed were only 8.7%. Of the diabetic patients 70.3% patients were microbiologically confirmed and 29.7% were clinically diagnosed to have TB. In Non diabetic patients 64.6% were microbiologically confirmed and 35.4 % were clinically diagnosed. CONCLUSION:The association between Diabetes mellitus and TB is well documented and there is substantial evidence to support the fact that diabetes is an important risk factor for TB and conversely it is also possible that TB can induce glucose intolerance and also deteriorate glycemic control in subjects with diabetes. . Screening patients with Tuberculosis for diabetes will help in early detection of diabetes and further management thereby improving the efficacy of treatment.

Keywords: Tuberculosis, Multi-Drug Resistant, Extensive Drug Resistant

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