April - June 2019

Assessment of Alkaline Phosphatase activity in Gingival Crevicular Fluid as a Skeletal Maturity Indicator

Chirag Patil1

1Private Consultant, Orthodontist, UniqueDental Care, Valsad


BACKGROUND AND OBJECTIVES: The aim of the study was to evaluate gingival crevicular fluid (GCF) alkaline phosphatase (ALP) activity in growing subjects in relation to stages of skeletal maturation, ie, the growth phase, as prepubertal, pubertal, and postpubertal. METHODS: Sixty healthy growing subjects (27 girls and 33 boys; age range, 9 – 18 years) were enrolled in this study that followed a double-blind, prospective, cross-sectional design. Collection of GCF was performed at the mesial and distal sites of both central incisors, for the maxilla and mandible. Growth phase was assessed through the hand wrist radiograph using Bjork and Grave method. GCF parameter was expressed as total ALP activity.RESULTS: The total GCF ALP activity showed a peak for the pubertal growth phase. No differences were seen between the maxillary and mandibular sites, or between the sexes, for any GCF parameter.. CONCLUSION: The GCF ALP activity has potential as a diagnostic aid for identification of the pubertal growth phase in individual subjects

Keywords: Gingival crevicular fluid; Alkaline phosphatase activity; Growth phase; Skeletal maturity; Orthodontics

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