JOURNAL COVER PAGE
 
 
 
 
VOLUME 8,ISSUE 2
April - June 2019
 
Abstract

Significance of micronuclei (MN) scoring in various epithelial lesions- special emphasis on Breast lesions

Shamim S. Sheikh , Vijay C. Popat , Mona Der

1 Associate professor, Department of Pathology, M.P.Shah Medical College, Jamnagar, Gujarat.
2 Professor and Head, Department of Pathology, M.P.Shah Medical College, Jamnagar, Gujarat.
3 Senior Resident, Department of Pathology, M.P.Shah Medical College, Jamnagar, Gujarat.

ABSTRACT

BACKGROUND AND OBJECTIVES: Cancer is genomic disease associated with genetic damage accumulation. Majority of solid tumors show large number of chromosomal aberrations.Carcinoma of breast is on rise in our country. Like other cancers even breast carcinomas are known to have chromosomal instabilities that play an important role in cancer development and progression METHODS: The study consisted of 100 patients in which breast lesions, cervical lesions and liver lesions were included. Patients of all ages and both sexes were included. Our hospital is a tertiary care hospital and most of the patients are from lower economic group. After staining & mounting procedure micronuclei were counted. Scoring is done per 1000 epithelial cells in light microscopy. RESULTS: MN scoring on the cytology smear is a tedious process but it is cheap & readily be done in any laboratory in routinely processed & stained smears CONCLUSION: MN scoring on the epithelial cells of cervix could be used as biomarker in cancer screening . This is an easy, simple, reliable, reproducible & objective test which can be performed on routinely stained pap smears.

Keywords: Micronucleus, Scoring, Genetic


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