January - March 2021

Assessment of the necessity of serum amylase in diagnosis of acute pancreatitis: A Retrospective study

Ajay M. Rajyaguru1*, Twinkal R. Upadhyay2, Amit Chauhan3, Rahul Chaudhry4, Vikrant Patel5, Jatin Bhatt6

1MS, General Surgery, FMAS, FIAGES, Associate Professor, 2MBBS, MD, Biochemistry, Clinical Biochemist
3MBBS,3rd year Resident General Surgeon, 4MBBS,3rd year Resident General Surgeon, 5MBBS,2nd  year Resident general surgeon, 6MS, FIAGES, FMAS, Professor & Head, Department of Surgery, P. D. U. Medical College & Hospital Rajkot


OBJECTIVES: To assess the need of  serum amylase and lipase in acute pancreatitis. STUDY: Retrospective observational study PARTICIPANTS: Patients admitted with acute pancreatitis in surgery department  from February 2014 to January 2016 were included in the study. METHODS: Data from previous records that included demographics, laboratory results and etiology. RESULTS: Among  96 acute pancreatitis(AP) patients, gallstones (n=42) were the most common cause. The majority patients (62.5%) with AP  had raised levels of both amylase and lipase. Raised lipase levels only were observed in additional 16.66% and 31.81% of patients with gallstone induced  and alcohol-induced pancreatitis, respectively. Overall, raised lipase levels were seen in between 96.66% and 100% of patients based on aetiology. Sensitivity and specificity of lipase in the diagnosis of AP was 97.89% and 99.7%, respectively. In contrast, the sensitivity and specificity of amylase in diagnosing AP  were 73.68% and 99.2%,respectively. CONCLUSIONS: Serum lipase level estimation alone is sufficient to diagnose AP.
keywords:   Serum amylase, serum lipase, acute pancreatitis(AP)

Keywords: Assessment of the necessity of serum amylase

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