January - March 2021

A Clinical Comparison Of Safety And Efficacy Of Levobupivacaine And Bupivacaine In Supraclavicular Brachial Plexus Block: A Prospective, Randomized, Double Blind, Clinical Trial

Deepika Dash1*, Shilpa M. Doshi2, D. C. Tripathi3

13rd year resident doctor, 2Associate professor, 3Head of the Department and Professor, Department of Anesthesiology, Government Medical College n Sir T Hospital, Bhavnagar



AIMS AND OBJECTIVES: Bupivacaine in supraclavicular brachial plexus block is well known & very potent local anaesthetic but it is highly cardiotoxic and neurotoxic. It’s recently introduced isomer levobupivacaine is proved to be less cardiotoxic and neurotoxic.  The primary end points are the onset, peak and duration of sensory and motor block and duration of post operative analgesia, effect on hemodynamic variables & complications of drug. MATERIAL AND METHODS: After IRB approval & informed written consent from the patient, study was conducted in 120 patients of 20-50 years of either gender of ASA-I/II posted for elective upper limb orthopaedic surgeries for 2 years duration. Patients were randomized using sealed envelopes technique in 2 groups. (group B-30 ml 0.5% bupivacaine/ group L-30 ml 0.5% levobupivacaine). Primary study criteria include sensory and motor characteristics and post operative analgesia while hemodynamic variables and complications were included in secondary criteria. Inter group comparison of quantitative and qualitative data was done by Z test and Chi square test respectively. Statistical analysis was done by graph pad instat-3 software trial version. RESULTS: Demographic data were comparable in both the groups. The onset, peak and duration of sensory and motor blockade & duration of effective analgesia were comparable in both the groups. Vital parameters were within their clinical limit and comparable. CONCLUSION: It is to be concluded that bupivacaine and levobupivacaine are equally effective and safe.


Key words: Levobupivacaine, bupivacaine, supraclavicular brachial plexus block, sensory and motor block.


Keywords: A Clinical Comparison Of Safety And Efficacy

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