January - March 2021

Assessment  Of Renal Functions In Neonates Of Perinatal Asphyxia

Parsawala Khushboo M1*, Javadekar Bakul B2

1consulting pediatrician, 2professor and head, department of pediatrics at Baroda medical college and SSG hospital Baroda



BACKGROUND: prospective case controlled study was conducted in the NICU of a tertiary level teaching hospital for assessment of renal functions in asphyxiated neonates and to correlate severity and type of renal failure with hypoxic ischemic encephalopathy (HIE) grading of the neonates. 64 neonates for perinatal asphyxia and 64 babies selected randomly from non asphyxiated babies for the control group. Blood samples were taken for measurement of serum urea, creatinine, sodium and potassium levels on 1st and 3rd day of  life. If any abnormality detected,values were repeated every alternate days till it become normal. Blood urea and serum creatinine were significantly higher in asphyxiated babies compared to the control group (P<0.001). Biochemical derangements correlated well with HIE staging. Among 64 cases 28 (43.75%) had elevated levels of urea and creatinine on day 1 [Mean urea (43.21± 23.08), creatinine (1.14 ± 0.57)], 36 (56.25%) had elevated levels of urea and creatinine on day 3.Mean urea (58.06 ±28.52) and creatinine (1.24±0.5) were significantly higher on day 3 (p value<0.05) in study group as compared to control. Mean urea and creatinine levels showed increasing trend with degree of severity of hypoxic ischaemic encephalopathy. Eighteen babies with perinatal asphyxia developed renal failure (56.25%). 18 had Hyponatremia on day 1 (56.25%), 3 of them had value < 125 meq/l. Though, mean sodium and potassium level was within the normal limit, the value of potassium was higher among cases than controls.


Key words: Perinatal asphyxia, Hypoxic Ischaemic Encephalopathy, Renal failure.

Keywords: Assessment Of Renal Functions

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