January - March 2021

A Study of Serum Urea, Creatinine and Uric Acid Levels In Hypothyroid Patients

Gagandeep Kaur Sidhu1*, Rahima.R.Malek2, Asha Khubchandani3, Sohil.H.Mansuri4, Miku.S.Patel5 , Ruhan.H. Oza6

1,3Associate Professor, 2,5,6Post-graduate student, Biochemistry Department, B.J. Medical College and Civil Hospital, Ahmedabad, 4MD  PSM; SMO; WHO; Hamirpur



 BACKGROUND: Hypothyroidism is a progressive disorder that presents with diverse degrees of thyroid failure and metabolic consequences. The objective of this study was to determine the effects of thyroid dysfunction on serum values of Urea, Creatinine & Uric acid.  MATERIALS AND METHODS: A cross-sectional study was done and included 100 individuals (50 hypothyroid cases and 50 normal controls).  Serum TSH levels were estimated by Chemiluminescent icroparticleImmunoassay(CMIA) method to assess the hypothyroid cases.Serum Urea, Creatinine & Uric acid were estimated by colorimetric method on fully automated chemistry analyser. RESULT:Serum Urea, Creatinine & Uric acid levels were significantly elevated in hypothyroid group as compared to euthyroid controls. CONCLUSION: Hypothyroid state is associated with hemodynamic changes like reduction in renal plasma flow and glomerular filtration rate, which causes increase in the levels of serum urea, creatinine and uric acid. Purine metabolism is also affected by disturbance in thyroid hormones, leading to alteration in the uric acid levels, leading to hyperuricemia and gout. Hence these parameters should be regularly monitored in hypothyroid patients.


Keywords: hypothyroid, serum TSH, urea, creatinine, uric acid

Keywords: Creatinine and Uric Acid Levels In Hypothyroid Patients

[Full Text Article]