January - March 2021

Diagnostic and prognostic role of CA 15-3 in breast carcinoma

Charmi R. Vyas1, Vijay C. Popat2*, P. M. Santwani3, Suresh Bhanushali4, Deval Mehta5

1,5Tutor, 2Associate professor, 3Professor & Head, 4Ex. Resident in pathology, M. P. Shah medical college, Jamnagar



BACKGROUND:  Breast cancer is one of the most common malignancy among women in most developed and developing regions of the world with nearly a million new cases each year. Prognosis of Breast cancer depends on evaluaton of various parameters like tumor histologic grading, cell proliferation index, estrogen receptor status and lymph node status is of growing interest3. CA 15-3 mucin belonging to a large family of glycoprotien’s encoded by the MUC1 gene. CA 15-3 determination is particularly useful in evaluating recurrence of disease and response to treatment. CA 15-3 is the most sensitive marker for the diagnosis of secondary breast cancer7. MATERIAL AND METHODS: For these purpose patients who were admitted in various wards like surgery and radiotherapy at G.G. Government hospital Jamnagar  were considered. Total 100 cases studied.These included patients with suspected carcinoma of breast and presenting with lump in breast, pain, or discharge from nipple. Some cases presented directly with the metastatic disease and complaints of bone pain. These patients were investigated for CA 15-3 levels in their serum with the use of ELISA (Enzyme Linked Immunosorbant Assay) test. Both Pre operative and post operative values were operative values were measured in few cases to see the changes in CA 15-3 value after tumor resection.OBSERVATION  AND  RESULT: Marker levels were correlated with the histopathological findings like size, grade etc.pre and post operative values were measured for prognostic purpose, to monitor response to treatment and to detect recurrence and metastasis. Detailed history , clinical examination, investigation, gross findings, microscopic cytological and histopathological findings were evaluated and following observations and results were found. In present study it was observed that majority of patients belonged to age group of 41-60 yrs, In majority of patients size of  leasion was between 2-5cm and grade was 2. It was found that mean pre op and post op CA 15-3 was higher in metastatic and recurrent cases than other cases. It was found that post treatment CA 15-3 is 83.3% sensitive and 98.1% specific in detection of recurrent or metastatic diseases. CONCLUSIONS:CA 15-3 is one of the first circulating prognostic factors for breast cancer. Preoperative concentrations thus might be combined with existing prognostic factors for predicting outcome in patients with newly diagnosed breast cancer. At present, the most important clinical application of CA 15-3 is in monitoring therapy in patients with advanced breast cancer that is not assessable by existing clinical or radiologic procedures.


Key words: CA 15-3, serum tumor marker, breast carcinoma, prognosis



Keywords: Diagnostic and prognostic role of CA 15-3 in breast carcinoma

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