JOURNAL COVER PAGE
 
 
 
 
VOLUME 10,ISSUE 1
January - March 2021
 
Abstract

Intravenous Rabeprazole Versus Ranitidine For Improving  Preoperative Gastric Fluid Properties In Adults Under Going Elective Surgery Under General Anaesthesia - A Prospective, Randomized, Double Blind, Controlled, Clinical Study.

Amit Kumar Khare1*, Lopa H Trivedi2, D.C.Tripathi3, harshil j. Gandhi4

1,43rd year Resident, 2Associate Professor, 3Professor &HOD, Department of Anesthesiology, Government Medical College & Sir T Hospital, Bhavnagar, Gujarat, India.

ABSTRACT

BACKGROUND: We compared the effect of Rabeprazole and Ranitidine given intravenously as premedication to improve the preoperative gastric fluid properties as prophylaxis against aspiration lung injury. PATIENTS & METHODS: The present study was conducted in 100 patients of age18-60years, of either sex, of ASA-PS Ι&ΙΙ, undergoing elective surgery under general anaesthesia in a prospective double blind manner. The patients were kept fasting over night, one hour prior to surgery, patients were randomly allocated (computer generated number) in two groups. Group Ι received Rabeprazole (20mg) i.v. and Group ΙΙ Ranitidine (50mg) i.v. One hour after the premedication, gastric contents were aspirated to record volume and pH. Quantitative data (mean±SD) of the groups were compared with student t test using graph pad in stat 3. The difference between the two groups was said to be statistically significant if p < 0.05. RESULTS: The administration of intravenous Rabeprazole and Ranitidine 1 hour prior to surgery is effective in reducing gastric fluid acidity and volume below the critical level (volume=25ml & pH=2.5). As compared to Rabeprazole, Ranitidine significantly decreases gastric fluid volume while both drugs show no significant difference in increasing gastric pH. CONCLUSION: This study shows that as compared to Rabeprazole, Ranitidine is more effective.

 

Keywords- Rabeprazole, Ranitidine, Gastric fluid volume, Gastric fluid pH

 

ABSTRACT

ABSTRACT

BACKGROUND: We compared the effect of Rabeprazole and Ranitidine given intravenously as premedication to improve the preoperative gastric fluid properties as prophylaxis against aspiration lung injury. PATIENTS & METHODS: The present study was conducted in 100 patients of age18-60years, of either sex, of ASA-PS Ι&ΙΙ, undergoing elective surgery under general anaesthesia in a prospective double blind manner. The patients were kept fasting over night, one hour prior to surgery, patients were randomly allocated (computer generated number) in two groups. Group Ι received Rabeprazole (20mg) i.v. and Group ΙΙ Ranitidine (50mg) i.v. One hour after the premedication, gastric contents were aspirated to record volume and pH. Quantitative data (mean±SD) of the groups were compared with student t test using graph pad in stat 3. The difference between the two groups was said to be statistically significant if p < 0.05. RESULTS: The administration of intravenous Rabeprazole and Ranitidine 1 hour prior to surgery is effective in reducing gastric fluid acidity and volume below the critical level (volume=25ml & pH=2.5). As compared to Rabeprazole, Ranitidine significantly decreases gastric fluid volume while both drugs show no significant difference in increasing gastric pH. CONCLUSION: This study shows that as compared to Rabeprazole, Ranitidine is more effective.

 

Keywords- Rabeprazole, Ranitidine, Gastric fluid volume, Gastric fluid pH

 

Keywords: A Prospective, Randomized, Double Blind, Controlled, Clinical Study.


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